21st Century Clinical Trials

Research Team

Cai, Tianxi

Professor of Biostatistics
Harvard T.H. Chan School of Public Health
Professor of Biomedical Informatics
Harvard Medical School

Parast, Layla

Statistician
Rand Corporation

Tian, Lu

Professor of Biomedical Data Science
Stanford University

Uno, Hajime

Assistant Professor
Medicine, Harvard Medical School
Assistant Professor
Biostatistics and Computational Biology
Dana-Farber Cancer Institute

Wei, Lee Jen

Professor of Biostatistics
Harvard T.H. Chan School of Public Health

Selected Publications

L Parast, T Cai, L Tian. “Using a surrogate marker for early testing of a treatment effect”. Biometrics 2019;75(4):1253–1263.
X Wang, L Parast, L Tian, T Cai. “Model-free approach to quantifying the proportion of treatment effect explained by a surrogate marker”. Biometrika 2019;107(1):107–122.
T Cai, T Cai, Z Guo. “Individualized Treatment Selection: An Optimal Hypothesis Testing Approach In High-dimensional Models”. arXiv 2019;1904.12891.
L Parast, L Tian, T Cai. “Assessing the value of a censored surrogate outcome”. Lifetime Data Analysis 2019;26(2):245–265.
L Parast, T Cai, L Tian. “Evaluating surrogate marker information using censored data”. Statistics in Medicine 2017;36(11):1767–1782.
H Uno, J Wittes, H Fu, SD Solomon, B Claggett, L Tian, T Cai, MA Pfeffer, SR Evans, L Wei. “Alternatives to Hazard Ratios for Comparing the Efficacy or Safety of Therapies in Noninferiority Studies”. Annals of Internal Medicine 2015;163(2):127.
RA Matsouaka, J Li, T Cai. “Evaluating marker-guided treatment selection strategies”. Biometrics 2014;70(3):489–499.
L Parast, L Tian, T Cai. “Landmark Estimation of Survival and Treatment Effect in a Randomized Clinical Trial”. Journal of the American Statistical Association 2014;109(505):384–394.
L Zhao, L Tian, T Cai, B Claggett, LJ Wei. “Effectively Selecting a Target Population for a Future Comparative Study”. Journal of the American Statistical Association 2013;108(502):527–539.
T Cai, L Tian, PH Wong, LJ Wei. “Analysis of randomized comparative clinical trial data for personalized treatment selections”. Biostatistics 2010;12(2):270–282.
L Tian, T Cai, MA Pfeffer, N Piankov, P- Cremieux, LJ Wei. “Exact and efficient inference procedure for meta-analysis and its application to the analysis of independent 2 x 2 tables with all available data but without artificial continuity correction”. Biostatistics 2008;10(2):275–281.